TAF1抗体;TAF1 Antibody—艾普蒂

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     Western blot analysis of TAF1 expression in SH-SY5Y cell lysate.    

  
  

TAF1 (TATA-box binding protein-associated factor 1) is a critical subunit of the TFIID complex, a general transcription factor essential for RNA polymerase II-mediated initiation of gene transcription. As the largest component of TFIID, TAF1 plays dual roles in transcription regulation: it facilitates the assembly of the pre-initiation complex at promoter regions and possesses intrinsic enzymatic activities, including histone acetyltransferase and kinase functions, which modulate chromatin structure and transcriptional activation. TAF1 is ubiquitously expressed and evolutionarily conserved, underscoring its fundamental role in cellular processes such as development, cell cycle progression, and stress response.

Antibodies targeting TAF1 are vital tools for studying its expression, localization, and interactions in diverse experimental contexts. They are widely used in techniques like Western blotting, immunoprecipitation, chromatin immunoprecipitation (ChIP), and immunofluorescence to investigate TFIID complex dynamics, promoter-specific transcriptional regulation, and epigenetic modifications. Dysregulation of TAF1 has been implicated in diseases, including cancers (e.g., hepatocellular carcinoma, colorectal cancer) and neurodevelopmental disorders like X-linked dystonia-parkinsonism (XDP), where TAF1 mutations or altered expression disrupt normal transcriptional programs. Researchers also utilize TAF1 antibodies to explore its role in cellular differentiation, apoptosis, and responses to DNA damage. Commercial availability of TAF1-specific antibodies (polyclonal or monoclonal) enables standardized reproducibility across studies, though validation for species cross-reactivity and application-specific performance remains essential.