betaDefensin1抗体;betaDefensin1 Antibody—艾普蒂 新品

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     Western blot analysis of beta Defensin 1 expression in Human recombinant beta Defensin 1 lysate.    

  
  

Beta-defensin 1 (BD-1), encoded by the *DEFB1* gene in humans, is a small cationic antimicrobial peptide belonging to the defensin family. It plays a critical role in innate immunity, particularly at epithelial surfaces such as skin, respiratory tract, and oral mucosa. BD-1 is constitutively expressed or induced during infection, acting as a first-line defense against pathogens by disrupting microbial membranes and modulating immune responses. Its structure, characterized by six conserved cysteine residues forming three disulfide bonds, stabilizes its functional β-sheet conformation.

Antibodies targeting beta-defensin 1 are essential tools for studying its expression, localization, and function in both healthy and diseased tissues. These antibodies are widely used in techniques like immunohistochemistry, Western blotting, and ELISA to investigate BD-1's involvement in infections, inflammatory disorders (e.g., psoriasis, cystic fibrosis), and cancer. Research has linked *DEFB1* polymorphisms to susceptibility to chronic inflammatory conditions, driving interest in BD-1 as a potential therapeutic target or biomarker.

Commercial BD-1 antibodies are typically raised in rabbits or mice using synthetic peptides or recombinant proteins as immunogens. Validation includes testing on knockout controls or recombinant BD-1 to ensure specificity. Beyond basic research, BD-1 antibodies may have diagnostic applications, particularly in assessing mucosal immunity or monitoring disease progression. Challenges remain in standardizing detection due to BD-1's low molecular weight and structural similarities to other defensins.