DMRT1抗体;DMRT1 Antibody—艾普蒂 新品

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     Western blot analysis of DMRT1 expression in HL-60 cell lysate.    

  
  

DMRT1 (Doublesex and Mab-3 Related Transcription factor 1) is a conserved zinc finger-like transcription factor critical for vertebrate sexual development and gametogenesis. It plays a pivotal role in testis determination, differentiation of Sertoli cells, and maintenance of germ cell identity across species. The DMRT1 protein contains a DNA-binding DM domain, enabling regulation of target genes involved in sex determination pathways. In mammals, DMRT1 is predominantly expressed in fetal gonads and adult testes, with mutations or deletions linked to disorders of sexual development, including gonadal dysgenesis and sex reversal.

DMRT1 antibodies are essential tools for studying its expression patterns, molecular interactions, and functional mechanisms. These antibodies are widely used in techniques like Western blotting, immunohistochemistry, and chromatin immunoprecipitation (ChIP) to investigate DMRT1's spatiotemporal localization, protein levels, and regulatory networks. Commercially available antibodies are typically raised against specific epitopes, such as the N-terminal or DM domain, with validation in model organisms (e.g., mice, chickens, fish) reflecting DMRT1's evolutionary conservation. Their applications span developmental biology, reproductive disorders, and cancer research, particularly in tumors with disrupted sexual differentiation pathways. Quality validation (e.g., knockout controls) is crucial due to potential cross-reactivity with other DM domain proteins.