ApoA抗体;ApoA Antibody—艾普蒂 新品

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     Western blot analysis of ApoA expression in Human plasma lysate.    

  
  

**Background of ApoA Antibodies**

Apolipoprotein A (ApoA) is a key structural and functional component of high-density lipoprotein (HDL), playing a critical role in cholesterol metabolism and cardiovascular health. The ApoA family, primarily ApoA-I and ApoA-II, facilitates reverse cholesterol transport by mediating HDL assembly and interacting with cellular receptors. ApoA-I, the major protein in HDL, promotes cholesterol efflux from peripheral tissues to the liver for excretion, while ApoA-II modulates HDL stability and metabolism.

Antibodies targeting ApoA subtypes (e.g., anti-ApoA-I, anti-ApoA-II) are essential tools for studying HDL biology and its link to diseases like atherosclerosis. These antibodies enable the detection, quantification, and functional characterization of ApoA proteins in assays such as ELISA, Western blotting, and immunohistochemistry. In research, they help investigate how ApoA levels or mutations correlate with cardiovascular risk, inflammation, or metabolic disorders.

Clinically, autoantibodies against ApoA-I have been implicated in autoimmune conditions and cardiovascular pathologies, serving as potential biomarkers for disease progression. Therapeutic strategies leveraging ApoA mimetics or recombinant ApoA also rely on antibody-based validation. However, variability in antibody specificity (monoclonal vs. polyclonal) and cross-reactivity across species requires careful validation to ensure experimental accuracy. Overall, ApoA antibodies remain pivotal in advancing both basic research and translational applications in lipid metabolism and cardiovascular disease.