ATOH1抗体;ATOH1 Antibody—艾普蒂

The ATOH1 antibody detects the Atonal homolog 1 (ATOH1) protein, a basic helix-loop-helix (bHLH) transcription factor critical in cell differentiation and tissue development. Initially identified in Drosophila as a neurogenic gene, ATOH1 regulates the specification of progenitor cells into distinct lineages, particularly in the nervous system, inner ear, and intestinal epithelium. It is essential for the development of cerebellar granule neurons, cochlear hair cells, and secretory cells in the gut. Dysregulation of ATOH1 is linked to developmental disorders and cancers. For example, its loss promotes colorectal tumorigenesis, while overexpression drives medulloblastoma. The ATOH1 antibody is widely used in research to study neural development, cancer mechanisms, and regenerative medicine. It aids in identifying ATOH1-expressing cells via techniques like immunohistochemistry, Western blotting, or immunofluorescence. Commercially available antibodies are typically validated for specificity using knockout controls or peptide blocking assays. Recent studies also explore ATOH1's role in cellular reprogramming, offering potential therapeutic avenues for hearing loss or neurodegenerative diseases. Researchers must consider tissue-specific expression patterns and post-translational modifications when interpreting results.