TIM50抗体;TIM50 Antibody—艾普蒂 新品

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     Western blot analysis of NAT1 expression in LnCaP cell lysate.    

  
  

The TIM50 antibody is a crucial tool for studying the TIM50 protein, a key component of the mitochondrial inner membrane translocase machinery. TIM50. part of the TIM23 complex, plays a vital role in importing nuclear-encoded proteins into the mitochondrial matrix by facilitating substrate recognition and translocation across the inner membrane. It also regulates mitochondrial membrane potential, dynamics, and apoptosis by interacting with other translocase components (e.g., TIM23. TIM44) and stress-responsive proteins. Dysfunction of TIM50 is linked to mitochondrial disorders, neurodegeneration, and cancer.

The TIM50 antibody enables the detection and quantification of TIM50 expression in various experimental models (e.g., Western blot, immunofluorescence, immunoprecipitation), aiding research on mitochondrial protein import mechanisms, cellular stress responses, and disease pathogenesis. It is widely used to investigate mitochondrial dysfunction in conditions like Parkinson’s disease, metabolic syndromes, and chemotherapy resistance. Commercial TIM50 antibodies are typically raised in rabbits or mice against specific epitopes, with validation in multiple species. Researchers rely on its specificity to explore TIM50’s regulatory roles in energy metabolism, apoptosis, and aging, making it essential for advancing mitochondrial biology and therapeutic targeting.