5HT7Receptor抗体;5HT7Receptor Antibody—艾普蒂 新品

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     All lanes use the Antibody at 1:1K dilution for 1 hour at room temperature.    

  
  

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     All lanes use the Antibody at 1:1K dilution for 1 hour at room temperature.    

  
  

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     All lanes use the Antibody at 1:1K dilution for 1 hour at room temperature.    

  
  

The 5-HT7 receptor, a member of the G protein-coupled receptor (GPCR) family, is one of seven serotonin receptor subtypes (5-HT1–7) that mediate the diverse physiological effects of serotonin. Primarily expressed in the central nervous system (CNS), it plays key roles in regulating circadian rhythms, mood, sleep-wake cycles, and cognitive functions. Unlike other serotonin receptors, the 5-HT7 receptor is also found in peripheral tissues, including the gastrointestinal tract and vascular smooth muscle, highlighting its broader functional significance.

Antibodies targeting the 5-HT7 receptor are critical tools for studying its expression, localization, and function. These antibodies are commonly used in techniques like Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF) to map receptor distribution in brain regions (e.g., hypothalamus, hippocampus) and peripheral tissues. Research leveraging these antibodies has linked 5-HT7 receptor dysregulation to neuropsychiatric disorders (e.g., depression, schizophrenia), migraines, and irritable bowel syndrome.

A major challenge in developing 5-HT7 receptor antibodies lies in ensuring specificity, as the receptor shares structural homology with other serotonin subtypes. High-quality antibodies are validated using knockout (KO) models or siRNA knockdown to confirm minimal cross-reactivity. Recent advances in epitope design and validation protocols have improved reliability, aiding drug discovery efforts targeting 5-HT7 for therapeutic interventions. Despite progress, the receptor’s complex signaling pathways and splice variants necessitate continued refinement of antibody tools to unravel its multifaceted roles in health and disease.