CytochromeP4501A2抗体;CytochromeP4501A2 Antibody—艾普蒂 新品

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     All lanes use the Antibody at 1:1K dilution for 1 hour at room temperature.    

  
  

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     All lanes use the Antibody at 1:1K dilution for 1 hour at room temperature.    

  
  

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     Western blot analysis of Cytochrome P450 1A2 expression in Caco2 cell lysate.    

  
  

Cytochrome P450 1A2 (CYP1A2) is a member of the cytochrome P450 enzyme family, primarily expressed in the liver and involved in the metabolism of xenobiotics, drugs, and endogenous compounds. It plays a critical role in detoxifying procarcinogens, such as polycyclic aromatic hydrocarbons (PAHs) and heterocyclic amines, while also contributing to the bioactivation of certain toxins. CYP1A2 activity is highly variable among individuals due to genetic polymorphisms, environmental factors (e.g., smoking, diet), and drug interactions, influencing drug efficacy and toxicity risks.

CYP1A2 antibodies are essential tools for studying the enzyme's expression, regulation, and function in both research and clinical settings. These antibodies enable the detection and quantification of CYP1A2 protein levels in tissues or cell lysates using techniques like Western blotting, immunohistochemistry, and ELISA. Researchers use them to investigate CYP1A2 induction mechanisms, particularly its upregulation via the aryl hydrocarbon receptor (AhR) pathway upon exposure to ligands like dioxins or PAHs. Additionally, CYP1A2 antibodies aid in exploring interactions with drugs (e.g., caffeine, clozapine) and assessing disease associations, such as liver disorders, cancer susceptibility, or metabolic syndromes. Their specificity and reliability are crucial for elucidating CYP1A2's role in pharmacology, toxicology, and personalized medicine.