Netrin1抗体;Netrin1 Antibody—艾普蒂 新品

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     All lanes use the Antibody at 1:1K dilution for 1 hour at room temperature.    

  
  

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     Western blot analysis of Netrin 1 expression in Human fetal brain lysate.    

  
  

Netrin-1 is a secreted laminin-related protein that plays a critical role in axon guidance, angiogenesis, and cell migration during embryonic development. It acts as a chemotropic cue, attracting or repelling growing axons by binding to receptors such as DCC (Deleted in Colorectal Cancer) and UNC5 family members. Beyond development, Netrin-1 is implicated in tissue repair, inflammation, and cancer progression, where it often exhibits upregulated expression in tumors, promoting cell survival, proliferation, and metastasis.

Antibodies targeting Netrin-1 are essential tools for studying its expression, localization, and functional mechanisms. These antibodies are widely used in techniques like Western blotting, immunohistochemistry, and immunofluorescence to detect Netrin-1 in biological samples. Some neutralizing antibodies block Netrin-1’s interaction with its receptors, enabling researchers to investigate its role in pathological processes, such as tumorigenesis or neuronal regeneration. Both monoclonal and polyclonal anti-Netrin-1 antibodies are available, with specificity validated across species including humans, mice, and rats.

Research utilizing Netrin-1 antibodies has revealed its dual role in cancer—acting as an oncogene in certain contexts while suppressing metastasis in others. Additionally, studies explore its potential as a therapeutic target, particularly in neural repair and anti-angiogenic therapies. Reliable Netrin-1 antibodies are thus vital for advancing understanding of its pleiotropic functions in health and disease.