Ube2N/Ubc13抗体;Ube2N/Ubc13 Antibody—艾普蒂 新品

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     Western blot analysis of Ube2N / Ubc13 expression in Daudi cell lysate.    

  
  

Ube2N (also known as Ubc13) is a member of the E2 ubiquitin-conjugating enzyme family, playing a critical role in the formation of Lys63 (K63)-linked polyubiquitin chains. These chains are essential for non-proteolytic signaling processes, including DNA damage repair, NF-κB activation, and inflammatory responses. Ube2N functions as a heterodimer with Uev1A or MMS2. enabling the specific assembly of K63-linked ubiquitin chains that recruit downstream effectors like TAK1 and IKK complexes. Its involvement in key pathways, such as the TNF-α/NF-κB axis and error-free DNA repair, underscores its importance in maintaining genomic stability and regulating immune signaling.

Antibodies targeting Ube2N/Ubc13 are widely used in research to study its expression, localization, and interactions in various biological contexts. These antibodies are critical tools for techniques like Western blotting, immunoprecipitation, and immunofluorescence, helping to dissect mechanisms in cancer, neurodegenerative diseases, and immune disorders. For instance, Ube2N inhibition or knockout models show impaired NF-κB signaling and increased sensitivity to genotoxic stress, highlighting its therapeutic relevance. Validated antibodies ensure specificity for distinguishing Ube2N from other E2 enzymes, aiding in the exploration of its dual roles in promoting cell survival (via DNA repair) or pathological inflammation. Researchers rely on these reagents to investigate Ube2N's contributions to diseases and its potential as a drug target.