GDF3抗体;GDF3 Antibody—艾普蒂

+ +

•  

   

     Western blot analysis of GDF3 expression in 293T cell lysate.    

  
  

Growth differentiation factor 3 (GDF3), a member of the TGF-β superfamily, is a secreted signaling protein involved in embryonic development, cell differentiation, and tissue homeostasis. It shares structural similarities with other TGF-β ligands but exhibits distinct functional roles, particularly in early embryogenesis and stem cell regulation. GDF3 is known to modulate BMP (bone morphogenetic protein) signaling pathways, often acting as a context-dependent antagonist or agonist to influence cell fate decisions. Studies highlight its importance in maintaining pluripotency in embryonic stem cells and regulating axial patterning during development. Dysregulation of GDF3 has been implicated in developmental disorders and diseases, including certain cancers, where it may promote tumor growth or metastasis.

GDF3 antibodies are essential tools for detecting and quantifying GDF3 protein expression in research. They enable the study of GDF3's spatial and temporal distribution in tissues, its interaction with receptors, and its role in signaling mechanisms. These antibodies are widely used in techniques like Western blotting, immunohistochemistry, and ELISA. Due to GDF3's overlapping functions with other TGF-β family members, antibody specificity is critical to avoid cross-reactivity. Recent research explores GDF3's potential as a therapeutic target or biomarker, particularly in oncology and regenerative medicine, driving demand for reliable antibodies to advance mechanistic and clinical studies.