XRCC3抗体;XRCC3 Antibody—艾普蒂

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     Western blot analysis of XRCC3 expression in HeLa cell lysate.    

  
  

**Background of XRCC3 Antibody**

The XRCC3 (X-ray repair cross-complementing protein 3) antibody is a tool used to detect and study the XRCC3 protein, a critical component of the DNA repair machinery. XRCC3 belongs to the RAD51 family and plays a pivotal role in homologous recombination repair (HR), a high-fidelity pathway essential for correcting DNA double-strand breaks (DSBs) and maintaining genomic stability. It interacts with RAD51C to form the RAD51C-XRCC3 complex, which stabilizes replication forks, facilitates sister chromatid exchange, and ensures accurate repair of damaged DNA.

Dysregulation or mutations in XRCC3 are linked to genomic instability, increased cancer susceptibility (e.g., breast, ovarian, and lung cancers), and hypersensitivity to DNA-damaging agents like ionizing radiation or chemotherapeutics. Researchers utilize XRCC3 antibodies in techniques such as Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF) to assess protein expression levels, subcellular localization, and its role in cancer progression or therapy resistance.

These antibodies are also valuable in studying the molecular mechanisms of DNA repair pathways and evaluating XRCC3 as a potential biomarker for predicting treatment outcomes in oncology. Their development and validation contribute to advancing personalized medicine and targeted therapies aimed at DNA damage response vulnerabilities.