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  • Dlx5抗体;Dlx5 Antibody—艾普蒂
  • Dlx5抗体;Dlx5 Antibody—艾普蒂
  • Dlx5抗体;Dlx5 Antibody—艾普蒂

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Dlx5抗体;Dlx5 Antibody—艾普蒂

Rabbit Monoclonal Dlx5 Antibody
询价 20μl 起订
50μl 起订
100μl 起订
上海 更新日期：2025-05-30

上海切尔齐生物科技有限公司

非会员
联系人：周***
电话：027***
手机：180***
邮箱：nuo***

产品详情:

中文名称：
Dlx5抗体
英文名称：
Rabbit Monoclonal Dlx5 Antibody
品牌：
艾普蒂
产地：
武汉
保存条件：
Stored at -20°C for 8527 year. Avoid repeated freeze / thaw cycles.
产品类别：
抗体
重组：
否
应用：
WB: IHC-P: IHC-F: ICC/IF: IP:FC:ChIP: ELISA
种属反应性：
Human,Mouse,Rat
宿主：
Rabbit
偶联物：
无
靶点：
Dlx5

验证与应用

应用及物种
WB1/1000-1/2000 Human,Mouse,Rat
IF1/20-1/50 Human,Mouse,Rat
IHCIHC:1/100-1/200;IHF:1/50-1/200 Human,Mouse,Rat
ICC1/50-1/200 Human,Mouse,Rat
FCM咨询技术 Human,Mouse,Rat
Elisa咨询技术 Human,Mouse,Rat
   

产品详情

AliasesDistal less homeo box 5; Dlx 5; Homeo box protein DLX 5;;DLX5
WB Predicted band size32 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman,Mouse,Rat
ImmunogenA synthesized peptide derived from human DLX5
FormulationPurified antibody in PBS with 0.05% sodium azide,0.05% BSA and 50% glycerol.

+ +

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       Western blot analysis of Dlx5 expression in (1) HeLa cell lysate; (2) RAW264.7 cell lysate.    


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       All lanes use the Antibody at 1:1K dilution for 1 hour at room temperature.    


  •  

     

       All lanes use the Antibody at 1:1K dilution for 1 hour at room temperature.    


  •  

     

       All lanes use the Antibody at 1:1K dilution for 1 hour at room temperature.    


  •  

     

       All lanes use the Antibody at 1:1K dilution for 1 hour at room temperature.    


  •  

     

       All lanes use the Antibody at 1:1K dilution for 1 hour at room temperature.    


  •  

     

       All lanes use the Antibody at 1:1K dilution for 1 hour at room temperature.    


  •  

     

       All lanes use the Antibody at 1:1K dilution for 1 hour at room temperature.    


           

参考文献

以下是3-4条关于Dlx5抗体的参考文献及其简要摘要内容：

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1. **文献名称**：*Dlx5 regulates regional development of the branchial arches and sensory capsules*

**作者**：Depew, M.J., et al.

**摘要**：研究利用Dlx5特异性抗体在小鼠胚胎中揭示Dlx5基因在鳃弓形态发生和感觉器官发育中的关键作用，抗体通过免疫组化证实其在颅面结构中的表达模式。

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2. **文献名称**：*The role of Dlx5 in osteogenic differentiation of mesenchymal stem cells*

**作者**：Lee, S.H., et al.

**摘要**：通过Western blot和免疫荧光(使用Dlx5抗体)，研究发现Dlx5在骨髓间充质干细胞向成骨细胞分化过程中显著上调，并调控Runx2等成骨相关基因。

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3. **文献名称**：*Dlx5 and Dlx6 function in mammalian cranial neural crest development*

**作者**：Acampora, D., et al.

**摘要**：利用Dlx5抗体进行胚胎组织染色，揭示Dlx5/Dlx6双敲除小鼠颅神经嵴细胞迁移异常，证明其对颅骨和牙齿发育的必要性。

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4. **文献名称**：*Aberrant Dlx5 expression promotes tumor invasion in glioblastoma*

**作者**：Wang, X., et al.

**摘要**：通过免疫组化(Dlx5抗体)发现胶质母细胞瘤中Dlx5异常高表达，其与肿瘤侵袭性和患者预后不良相关，机制涉及EMT通路激活。

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以上文献均通过Dlx5抗体的实验验证，涵盖发育生物学、干细胞分化及癌症研究领域。

       

背景信息

The Dlx5 antibody is a crucial tool in developmental biology and neuroscience research, targeting the Distal-less homeobox 5 (Dlx5) protein, a transcription factor encoded by the DLX5 gene. Dlx5 belongs to the DLX family of homeodomain proteins, which are evolutionarily conserved regulators of embryonic development, particularly in craniofacial patterning, limb formation, and neurogenesis. It plays a vital role in osteoblast differentiation, inner ear development, and GABAergic interneuron specification in the brain. Dysregulation of Dlx5 has been implicated in skeletal disorders, hearing loss, and neurological conditions.

Dlx5 antibodies are widely used to detect protein expression and localization via techniques like Western blotting, immunohistochemistry, and immunofluorescence. They help investigate Dlx5's involvement in tissue-specific gene regulation, cell fate determination, and disease mechanisms. Many commercially available Dlx5 antibodies are raised in hosts such as rabbits or mice, with validation across multiple applications. Researchers often employ them in studies on bone remodeling, stem cell differentiation, and neural crest cell migration. Specificity is confirmed using knockout controls or siRNA-mediated knockdowns to ensure minimal cross-reactivity with homologous proteins like Dlx6. As Dlx5 interacts with signaling pathways (e.g., BMP, Wnt), its antibody also aids in exploring molecular cascades during development and regeneration.

       
Dlx5抗体;Dlx5;Dlx5 Antibody;

公司简介

生物技术有限公司

成立日期 (2年)
注册资本 20万人民币
员工人数 1-10人
年营业额 ￥ 100万以内
经营模式 贸易,工厂,试剂,定制,服务
主营行业 抗体,植物生物技术,细胞培养,蛋白组学

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