PlastinL抗体;PlastinL Antibody—艾普蒂 新品

+ +

•  

   

     Western blot analysis of Plastin L expression in THP1 cell lysate.    

  
  

•  

   

     All lanes use the Antibody at 1:1K dilution for 1 hour at room temperature.    

  
  

PlastinL (L-plastin), also known as LCP1. is a calcium-regulated actin-bundling protein belonging to the plastin family, which includes T-plastin (PLST) and I-plastin. Primarily expressed in hematopoietic cells (e.g., lymphocytes, macrophages), it plays a critical role in cytoskeletal reorganization, cell migration, and immune responses. L-plastin stabilizes actin filaments by cross-linking them into parallel bundles, facilitating processes like immune cell adhesion, phagocytosis, and T-cell activation. Its activity is modulated by phosphorylation (e.g., Ser5/Ser7) via kinases like PKC, which enhances actin-binding capacity.

Anti-PlastinL antibodies are widely used in research to study immune cell dynamics, cancer metastasis (due to L-plastin overexpression in malignancies), and autoimmune/inflammatory diseases. These antibodies enable detection via techniques like Western blot, immunofluorescence, and flow cytometry, aiding in identifying cell-specific markers or signaling pathways. L-plastin’s involvement in immune deficiencies (e.g., Wiskott-Aldrich syndrome) and viral pathogenesis (e.g., HIV) further underscores its biomedical relevance. Commercially available antibodies often target conserved regions (e.g., N-terminal EF-hand domains) to ensure specificity across species. Ongoing research explores its potential as a diagnostic/prognostic biomarker or therapeutic target in oncology and immunology.