Neurogenin2抗体;Neurogenin2 Antibody—艾普蒂 新品

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     All lanes use the Antibody at 1:1K dilution for 1 hour at room temperature.    

  
  

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     Western blot analysis of Neurogenin 2 expression in SH-SY5Y cell lysate.    

  
  

Neurogenin2 (Ngn2) is a basic helix-loop-helix (bHLH) transcription factor critical in regulating neurogenesis during embryonic development. It plays a pivotal role in specifying neuronal cell fate, particularly in the central nervous system, by promoting the differentiation of neural progenitor cells into neurons while suppressing glial cell lineages. Ngn2 is transiently expressed during early neuronal commitment, making it a key marker for studying neurodevelopmental processes, neuronal differentiation, and cell lineage determination.

Antibodies targeting Neurogenin2 are essential tools for detecting and visualizing Ngn2 protein expression in various experimental models, including immunohistochemistry, Western blotting, and immunofluorescence. These antibodies enable researchers to map Ngn2's spatiotemporal expression patterns in tissues, assess its role in neuronal differentiation, and investigate its dysregulation in neurodevelopmental disorders or diseases. Specificity and validation (e.g., knockout controls) are critical for reliable results, as Ngn2 shares structural homology with other bHLH family members like Neurogenin1 and NeuroD.

Recent applications include stem cell research, where Ngn2 overexpression is used to reprogram fibroblasts or induced pluripotent stem cells (iPSCs) into functional neurons. Commercially available Ngn2 antibodies are often raised against conserved epitopes in human, mouse, or rat proteins, with validation in model organisms like zebrafish or chick embryos. Proper controls and species reactivity verification remain essential for experimental accuracy.