Frizzled9/CD349抗体;Frizzled9/CD349 Antibody—艾普蒂 新品

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     Western blot analysis of Frizzled 9 expression in Human Seminoma lysate.    

  
  

Frizzled9 (FZD9), also known as CD349. is a member of the Frizzled family of G protein-coupled receptors that serve as key mediators of the Wnt signaling pathway. This pathway is critical for embryonic development, tissue homeostasis, and stem cell regulation. FZD9 specifically binds Wnt proteins, activating canonical (β-catenin-dependent) or non-canonical signaling cascades to regulate cell proliferation, differentiation, and polarity.

Antibodies targeting FZD9/CD349 are essential tools for studying its expression, localization, and function in both physiological and pathological contexts. They are widely used in techniques like Western blotting, immunohistochemistry, and flow cytometry to investigate FZD9's role in cancers (e.g., colorectal, leukemia), neurological disorders (e.g., Alzheimer's), and developmental processes. Some studies highlight its overexpression in certain tumors, suggesting potential as a therapeutic target or biomarker.

Monoclonal antibodies against FZD9 often target extracellular cysteine-rich domains (CRD) for blocking ligand-receptor interactions, while polyclonal antibodies may detect broader epitopes for analytical purposes. Validation methods, such as knockout controls, are crucial due to homology among FZD family members. Research applications extend to drug development, aiming to modulate Wnt signaling in diseases linked to pathway dysregulation.