SynapsinII抗体;SynapsinII Antibody—艾普蒂 新品

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     Western blot analysis of Synapsin II expression in Human fetal brain lysate.    

  
  

Synapsin II is a member of the synapsin protein family, primarily expressed in neuronal presynaptic terminals. It plays a critical role in regulating synaptic vesicle trafficking, neurotransmitter release, and maintaining synaptic plasticity. Synapsin II interacts with cytoskeletal elements and synaptic vesicles, modulating their availability for exocytosis. Studies link Synapsin II dysfunction to neuropsychiatric disorders, including schizophrenia and bipolar disorder, as genetic variations in its encoding gene (SYN2) are associated with these conditions.

Synapsin II antibodies are essential tools for investigating its expression, localization, and function in neural tissues. These antibodies are widely used in techniques like Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF) to quantify protein levels, assess distribution in brain regions, or study changes under pathological conditions. For example, reduced Synapsin II levels observed in postmortem brain samples of schizophrenia patients highlight its potential role in disease mechanisms. Researchers also utilize these antibodies to explore synaptic alterations in neurodegenerative diseases (e.g., Alzheimer’s) or neurodevelopmental models.

Most Synapsin II antibodies target conserved epitopes, allowing cross-reactivity in human, rodent, and other mammalian species. Validation includes knockout controls to confirm specificity. As synaptic dysfunction underpins many neurological disorders, Synapsin II antibodies remain pivotal for advancing diagnostics and therapeutic strategies targeting synaptic integrity.