SYPL1抗体;SYPL1 Antibody—艾普蒂 新品

+ +

•  

   

     All lanes use the Antibody at 1:2K dilution for 1 hour at room temperature.    

  
  

•  

   

     All lanes use the Antibody at 1:1K dilution for 1 hour at room temperature.    

  
  

SYPL1 (Synaptophysin-like Protein 1) is a transmembrane protein belonging to the synaptophysin family, primarily localized to synaptic vesicles and secretory granules. It plays a role in vesicle trafficking, membrane fusion, and neurotransmitter release, with structural homology to synaptophysin but distinct tissue expression patterns. SYPL1 is implicated in regulating intracellular calcium signaling and exocytosis, particularly in neuronal and endocrine cells. Its dysregulation has been associated with neurological disorders, metabolic syndromes, and cancers, including melanoma and breast cancer, where altered expression may influence metastasis or chemoresistance.

SYPL1 antibodies are essential tools for detecting and characterizing the protein’s expression, localization, and interactions in research. They are widely used in techniques like Western blotting, immunofluorescence, and immunohistochemistry to study SYPL1’s physiological roles or pathological contributions. Commercially available antibodies often target specific epitopes, such as the C-terminal domain, to ensure specificity. Validation data, including knockout controls or siRNA knockdowns, are critical due to potential cross-reactivity with other synaptophysin family members. Research utilizing SYPL1 antibodies has expanded insights into vesicle dynamics, synaptic plasticity, and disease mechanisms, highlighting its potential as a biomarker or therapeutic target. Ongoing studies aim to clarify its molecular partners and signaling pathways in health and disease contexts.