KMT1B/SUV39H2抗体;KMT1B/SUV39H2 Antibody—艾普蒂 新品

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     Western blot analysis of KMT1B / SUV39H2 expression in (1) MOLT-4 cell lysate; (2) Human testis lysate.    

  
  

The KMT1B/SUV39H2 antibody is a crucial tool for studying the SUV39H2 protein, a member of the SUV39 subfamily of histone methyltransferases (HMTs). SUV39H2. also known as KMT1B, catalyzes the trimethylation of histone H3 at lysine 9 (H3K9me3), a hallmark of transcriptionally repressive heterochromatin. This enzyme plays a pivotal role in epigenetic regulation, maintaining genomic stability, and silencing retrotransposons. It shares functional redundancy with its paralog SUV39H1 (KMT1A), though SUV39H2 exhibits distinct expression patterns, including higher activity in germ cells and during early development. Dysregulation of SUV39H2 has been implicated in cancer, aging, and developmental disorders due to its influence on chromatin structure and gene expression.

The antibody targeting SUV39H2 enables researchers to detect and quantify its expression, localization, and interaction partners in various experimental settings, such as Western blotting, immunohistochemistry, and chromatin immunoprecipitation (ChIP). Validated antibodies are essential for distinguishing SUV39H2 from related HMTs, given the high sequence homology within the SUV39 family. Specificity is often confirmed using knockout controls or siRNA knockdown. Studies employing this antibody have shed light on SUV39H2's role in X-chromosome inactivation, telomere maintenance, and cellular differentiation. Its application in disease models further highlights its potential as a therapeutic target or biomarker for conditions linked to epigenetic dysregulation.