p53DINP1抗体;p53DINP1 Antibody—艾普蒂

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     Western blot analysis of p53 DINP1 expression in (1) HepG2 cell lysate; (2) RAW 264.7 cell lysate; (3) PC12 cell lysate.    

  
  

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     All lanes use the Antibody at 1:2K dilution for 1 hour at room temperature.    

  
  

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     All lanes use the Antibody at 1:2K dilution for 1 hour at room temperature.    

  
  

The p53DINP1 (p53-dependent damage-inducible nuclear protein 1) antibody is a tool used to study the p53 signaling pathway, which plays a central role in maintaining genomic stability and tumor suppression. p53DINP1. also known as CR673673 or C20orf43. is a stress-responsive protein transcriptionally activated by p53 under DNA damage or oxidative stress. It participates in cell cycle arrest, DNA repair, and apoptosis by interacting with key regulators like ATM/ATR kinases and modulating p53 activity through post-translational modifications.

The antibody specifically detects endogenous or overexpressed p53DINP1 protein in applications such as Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF). Its development aids in elucidating the protein's role in stress response, cancer biology, and aging. Researchers use it to analyze p53DINP1 expression patterns in normal versus tumor tissues, assess its regulation during therapeutic interventions (e.g., chemotherapy or radiation), and explore its interactions within p53-mediated pathways.

Validation of the antibody typically includes testing for specificity via knockout cell lines or siRNA knockdown. High-quality p53DINP1 antibodies are critical for understanding its dual role in promoting survival under mild stress or apoptosis under severe damage, offering insights into therapeutic strategies targeting p53-related diseases.