EphrinA1抗体;EphrinA1 Antibody—艾普蒂 新品

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     Western blot analysis of Ephrin A1 expression in HUVEC cell treated with TNF alpha.    

  
  

EphrinA1 antibodies are immunological tools designed to target ephrin-A1. a membrane-bound ligand belonging to the ephrin family, which interacts with Eph receptors (EphA subclass). EphrinA1 is a glycosylphosphatidylinositol (GPI)-anchored protein involved in bidirectional cell signaling, regulating processes like cell adhesion, migration, and tissue boundary formation. It plays critical roles in developmental biology, angiogenesis, and neurogenesis, and is implicated in pathological conditions, including cancer metastasis, inflammation, and vascular diseases.

EphrinA1 antibodies are widely used in research to study protein expression, localization, and signaling mechanisms. They enable detection via techniques such as Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF). Function-blocking EphrinA1 antibodies help dissect ligand-receptor interactions, particularly in tumor microenvironments where EphrinA1-EphA crosstalk influences cell proliferation and invasion. Conversely, activating antibodies can mimic ligand effects, aiding in pathway activation studies.

These antibodies are vital in exploring therapeutic potentials. For instance, in cancer research, EphrinA1 targeting may inhibit tumor angiogenesis or metastasis. In neurodegenerative studies, they help assess EphrinA1's role in axon guidance and synaptic plasticity. Commercial EphrinA1 antibodies are typically validated for specificity and affinity, with applications spanning basic research, drug discovery, and biomarker development. Their utility underscores the importance of EphrinA1 in both physiological and disease contexts, driving ongoing studies to harness its regulatory pathways for clinical interventions.