RORbeta抗体;RORbeta Antibody—艾普蒂 新品

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     Western blot analysis of ROR beta expression in HepG2 cell lysate.    

  
  

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     All lanes use the Antibody at 1:1K dilution for 1 hour at room temperature.    

  
  

The retinoid-related orphan receptor beta (RORβ), a member of the nuclear receptor superfamily, functions as a ligand-dependent transcription factor regulating gene expression involved in circadian rhythm, neural development, and photoreceptor differentiation. Primarily expressed in the retina, brain, and pineal gland, RORβ plays critical roles in maintaining retinal circuitry, dopaminergic signaling, and circadian clock machinery. Antibodies targeting RORβ are essential tools for investigating its expression patterns, molecular interactions, and pathological implications. These antibodies are commonly validated for applications like Western blotting, immunohistochemistry, and chromatin immunoprecipitation (ChIP), with specificity often confirmed using RORβ-knockout cell lines or tissues.

Research utilizing RORβ antibodies has revealed its association with neurological disorders (e.g., autism spectrum disorders), retinal degeneration, and cancer progression. For example, studies demonstrate RORβ's dual role as a tumor suppressor or promoter in different cancers, depending on cellular context. Challenges in antibody development include distinguishing between RORβ isoforms (RORβ1 and RORβ2) and minimizing cross-reactivity with homologous receptors (RORα/RORγ). High-quality RORβ antibodies remain crucial for advancing therapeutic strategies, such as designing RORβ-targeted drugs for circadian-related diseases or neurodegeneration. Recent efforts also focus on mapping RORβ's genomic targets through ChIP-seq to elucidate its regulatory networks in health and disease.