Syntrophinalpha1抗体;Syntrophinalpha1 Antibody—艾普蒂 新品

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     Western blot analysis of Syntrophin alpha 1 expression in A549 cell lysate.    

  
  

Syntrophin alpha 1 (SNTA1) is a cytoplasmic adapter protein belonging to the syntrophin family, which comprises five isoforms (α1. β1. β2. γ1. γ2) involved in organizing membrane-associated protein complexes. SNTA1 contains multiple protein interaction domains, including a PDZ domain, a pleckstrin homology (PH) domain, and a syntrophin unique (SU) domain, enabling it to act as a scaffold for signaling molecules, ion channels, and cytoskeletal proteins. It interacts with components of the dystrophin-glycoprotein complex (DGC), linking the extracellular matrix to the intracellular cytoskeleton in muscle and neuronal tissues. This interaction stabilizes cell membranes and facilitates signal transduction pathways, particularly those involving nitric oxide synthase (nNOS) and voltage-gated sodium channels.

SNTA1 dysfunction is implicated in neuromuscular disorders, such as congenital myopathies, and cardiac conditions like long QT syndrome and sudden cardiac death due to its role in ion channel regulation. Mutations in SNTA1 can disrupt protein-protein interactions, leading to aberrant electrical signaling or structural instability in cardiomyocytes and skeletal muscle cells.

Antibodies targeting SNTA1 are essential tools for studying its expression, localization, and molecular interactions. They are widely used in techniques like Western blotting, immunohistochemistry, and co-immunoprecipitation to investigate SNTA1's involvement in cellular processes and disease mechanisms. These antibodies help elucidate its contributions to membrane organization, ion homeostasis, and pathological conditions, aiding both basic research and potential therapeutic development.