SEC61A抗体;SEC61A Antibody—艾普蒂 新品

+ +

•  

   

     Western blot analysis of SEC61A expression in A431 cell lysate.    

  
  

The SEC61 complex, a conserved heterotrimeric protein channel embedded in the endoplasmic reticulum (ER) membrane, plays a central role in co-translational protein translocation and membrane integration. SEC61A (SEC61α) is the pore-forming α-subunit encoded by the *SEC61A1* gene in humans. It facilitates the transport of nascent polypeptides into the ER lumen and coordinates with ribosomes, signal recognition particles, and other translocon components. SEC61A antibodies are essential tools for studying ER-associated processes, including protein biosynthesis, quality control, and calcium homeostasis.

These antibodies are widely used in techniques like Western blotting, immunofluorescence, and immunohistochemistry to detect SEC61A expression, localization, and interactions. Research applications span cancer biology (e.g., SEC61A1 overexpression in certain tumors), congenital disorders (linked to *SEC61A1* mutations causing hematologic or neurodevelopmental defects), and ER stress responses. Commercial SEC61A antibodies are typically raised against epitopes in the N-terminal or C-terminal regions, with validation in specific experimental contexts critical due to potential cross-reactivity with homologous proteins.

Recent studies also explore SEC61A's role in modulating ER-phagy and its dysregulation in neurodegenerative diseases, highlighting its broader pathophysiological relevance.