CoREST抗体;CoREST Antibody—艾普蒂 新品

+ +

•  

   

     Western blot analysis of CoREST expression in Molt-4 cell lysate.    

  
  

CoREST antibodies are essential tools for studying the CoREST corepressor complex, a critical regulator of gene expression and chromatin remodeling. The CoREST protein (also known as RCOR1) was initially identified as a binding partner of REST (RE1-Silencing Transcription Factor), a repressor of neuronal genes in non-neuronal cells. However, CoREST functions both in REST-dependent and independent contexts, forming multi-protein complexes with histone-modifying enzymes like LSD1 (lysine-specific histone demethylase 1) and HDAC1/2 (histone deacetylases 1/2). These complexes mediate transcriptional repression by removing activating histone marks (e.g., H3K4me2 via LSD1) and promoting chromatin condensation.

CoREST antibodies are widely used in techniques such as ChIP-seq, immunofluorescence, and Western blotting to investigate its role in development, differentiation, and disease. Studies reveal CoREST's involvement in stem cell maintenance, neuronal development, and oncogenesis. Dysregulation of CoREST complexes is linked to cancers (e.g., leukemia, neuroblastoma) and neurological disorders. Antibodies targeting CoREST help characterize its interaction networks, subcellular localization, and dynamic recruitment to specific genomic loci. Notably, CoREST's dual role in gene repression and activation (via context-dependent partnerships) underscores its functional complexity, driving demand for high-specificity antibodies. Recent work also explores CoREST inhibitors as potential therapeutics, highlighting the translational relevance of these research tools.