SEC23抗体;SEC23 Antibody—艾普蒂 新品

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     Western blot analysis of SEC23 expression in HeLa cell lysate.    

  
  

SEC23 antibody targets the SEC23 protein, a critical component of the COPII (coat protein complex II) vesicle coat machinery involved in endoplasmic reticulum (ER)-to-Golgi transport. SEC23. along with SEC24. forms the inner layer of COPII-coated vesicles, facilitating cargo selection and vesicle budding from the ER. It acts as a GTPase-activating protein (GAP) for SAR1. promoting GTP hydrolysis and vesicle uncoating. Mammalian cells express two paralogs, SEC23A and SEC23B, which share structural similarity but exhibit tissue-specific expression and functional roles. SEC23B mutations are linked to congenital dyserythropoietic anemia type II (CDA II), underscoring its importance in erythropoiesis.

SEC23 antibodies are widely used in cell biology research to study secretory pathway dynamics, ER stress, and COPII-mediated trafficking. They are employed in techniques like Western blotting, immunofluorescence, and immunoprecipitation to localize SEC23. assess expression levels, or investigate interactions with COPII components. Commercially available antibodies are often validated for specificity across human, mouse, and rat samples. Researchers also utilize SEC23 antibodies to explore pathological mechanisms in cancers (e.g., SEC23A suppression in tumor metastasis) or genetic disorders tied to COPII dysfunction. Proper controls, such as knockout cell lines, are essential to confirm antibody specificity due to paralog homology.