NCX1抗体;NCX1 Antibody—艾普蒂 新品

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     Western blot analysis of NCX1 expression in K562 cell lysate.    

  
  

The Na+/Ca2+ exchanger 1 (NCX1) antibody is a crucial tool for studying the NCX1 protein, a bidirectional ion transporter encoded by the SLC8A1 gene. NCX1 plays a pivotal role in maintaining intracellular calcium homeostasis by exchanging three Na+ ions for one Ca2+ ion across cell membranes. It is highly expressed in excitable tissues, including cardiac muscle, smooth muscle, and neurons, where it regulates calcium efflux during relaxation and contributes to action potential dynamics. Dysregulation of NCX1 has been linked to cardiovascular pathologies (e.g., heart failure, arrhythmias), neurological disorders, and hypertension.

NCX1 antibodies are widely used in research to detect protein expression, localization, and functional changes via techniques like Western blotting, immunohistochemistry, and immunofluorescence. These antibodies are typically raised against specific epitopes of the NCX1 protein, such as intracellular regulatory domains or extracellular loops, and validated for species reactivity (e.g., human, mouse, rat). Monoclonal and polyclonal variants are available, with validation often including knockout controls to confirm specificity. Recent studies also utilize NCX1 antibodies to explore its role in ischemia-reperfusion injury, pharmacological responses, and crosstalk with other calcium-handling proteins like SERCA and RyR. Proper antibody selection depends on experimental goals, as post-translational modifications or tissue-specific splice variants (e.g., NCX1.1. NCX1.3) may affect detection.