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  • ATAD2抗体;ATAD2 Antibody—艾普蒂
  • ATAD2抗体;ATAD2 Antibody—艾普蒂
  • ATAD2抗体;ATAD2 Antibody—艾普蒂

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ATAD2抗体;ATAD2 Antibody—艾普蒂

Rabbit Monoclonal ATAD2 Antibody
询价 20μl 起订
50μl 起订
100μl 起订
上海 更新日期：2025-05-30

上海切尔齐生物科技有限公司

非会员
联系人：周***
电话：027***
手机：180***
邮箱：nuo***

产品详情:

中文名称：
ATAD2抗体
英文名称：
Rabbit Monoclonal ATAD2 Antibody
品牌：
艾普蒂
产地：
武汉
保存条件：
Stored at -20°C for 8379 year. Avoid repeated freeze / thaw cycles.
产品类别：
抗体
重组：
否
应用：
WB: IHC-P: IHC-F: ICC/IF: IP:FC:ChIP: ELISA
种属反应性：
Human,Mouse,Rat
宿主：
Rabbit
偶联物：
无
靶点：
ATAD2

验证与应用

应用及物种
WB咨询技术 Human,Mouse,Rat
IF咨询技术 Human,Mouse,Rat
IHC咨询技术 Human,Mouse,Rat
ICC1/50-1/200 Human,Mouse,Rat
FCM1/20-1/100 Human,Mouse,Rat
Elisa咨询技术 Human,Mouse,Rat
   

产品详情

AliasesANCCA; Atad2; CT137; L16; PRO2000;;ATAD2
WB Predicted band sizeCalculated MW: 159 kDa ; Observed MW: 180 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenA synthesized peptide derived from human ATAD2
FormulationPurified antibody in PBS with 0.05% sodium azide,0.05% BSA and 50% glycerol.

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       All lanes use the Antibody at 1:2K dilution for 1 hour at room temperature.    


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       Western blot analysis of ATAD2 expression in MCF-7 cell lysate.    


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       Immunofluorescent analysis using the Antibody at 1:150 dilution.    


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       Immunofluorescent analysis using the Antibody at 1:50 dilution.    


           

参考文献

以下是3篇关于ATAD2抗体的代表性文献摘要简述：

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1. **文献名称**: "ATAD2 is a novel cofactor for MYC, overexpressed and amplified in aggressive tumors"

**作者**: Ciro et al.

**摘要**: 研究利用ATAD2特异性抗体(兔多克隆)通过免疫组化(IHC)和免疫印迹(Western blot)发现，ATAD2在多种癌症(如乳腺癌、肺癌)中高表达，并与MYC协同促进肿瘤细胞增殖。抗体验证显示其特异性结合ATAD2的ATP酶结构域。

2. **文献名称**: "ATAD2 as a biomarker for poor prognosis in hepatocellular carcinoma"

**作者**: Zheng et al.

**摘要**: 通过ATAD2单克隆抗体(小鼠来源)对肝癌组织进行免疫组化分析，发现ATAD2高表达与患者生存期缩短显著相关。抗体特异性通过siRNA敲低实验验证，提示其可作为肝癌预后标志物。

3. **文献名称**: "ATAD2 interacts with CBP/p300 to regulate transcription and promote prostate cancer progression"

**作者**: Hu et al.

**摘要**: 使用ATAD2抗体(兔源，ChIP级别)进行染色质免疫沉淀(ChIP)和免疫荧光(IF)，揭示ATAD2通过结合组蛋白乙酰转移酶CBP/p300调控雄激素受体(AR)靶基因转录，促进前列腺癌转移。抗体特异性通过敲除细胞系验证。

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这些文献展示了ATAD2抗体在机制研究(如蛋白互作、转录调控)及临床诊断(如生物标志物筛选)中的关键应用。如需具体DOI或补充文献，可进一步提供。

       

背景信息

**Background of ATAD2 Antibody**

ATAD2 (ATPase family AAA domain-containing protein 2), also known as ANCCA or PRO2000. is a chromatin-associated protein implicated in transcriptional regulation, DNA replication, and cancer progression. It contains an AAA+ ATPase domain and a bromodomain, enabling its role in chromatin remodeling and interaction with acetylated histones or transcription factors. ATAD2 is overexpressed in various cancers, including breast, prostate, ovarian, and lung cancers, where it correlates with poor prognosis, tumor aggressiveness, and therapeutic resistance.

Functionally, ATAD2 acts as a co-activator for oncogenic transcription factors like MYC and estrogen receptor-alpha (ERα), promoting cell proliferation, survival, and metastasis. It also participates in DNA replication by facilitating the assembly of replication complexes. Due to its cancer-specific overexpression and critical roles in oncogenesis, ATAD2 is studied as a potential biomarker and therapeutic target.

ATAD2 antibodies are essential tools for detecting ATAD2 expression in research and diagnostics. They are used in techniques like Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF) to study ATAD2 localization, expression levels, and interactions in cancer models. Monoclonal and polyclonal antibodies targeting specific domains (e.g., bromodomain) help dissect its molecular mechanisms. Validated antibodies with high specificity are crucial, as cross-reactivity with homologous proteins (e.g., ATAD2B) may occur. Recent studies also explore ATAD2 inhibitors, underscoring the antibody's utility in preclinical drug development.

       
ATAD2抗体;ATAD2;ATAD2 Antibody;

公司简介

生物技术有限公司

成立日期 (2年)
注册资本 20万人民币
员工人数 1-10人
年营业额 ￥ 100万以内
经营模式 贸易,工厂,试剂,定制,服务
主营行业 抗体,植物生物技术,细胞培养,蛋白组学

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