SMARCC1/BAF155抗体;SMARCC1/BAF155 Antibody—艾普蒂 新品

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     Western blot analysis of SMARCC1 expression in HeLa cell lysate.    

  
  

SMARCC1 (SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily C member 1), also known as BAF155. is a core subunit of the SWI/SNF (BAF) chromatin remodeling complex. This evolutionarily conserved multiprotein complex utilizes ATP hydrolysis to modulate chromatin structure, regulating gene expression involved in cell differentiation, proliferation, and DNA repair. BAF155 plays a scaffolding role in maintaining complex integrity and directly interacts with DNA or transcription factors to guide target specificity.

Antibodies against SMARCC1/BAF155 are widely used to study SWI/SNF complex composition, localization, and function in developmental biology, cancer research, and epigenetic regulation. They are critical tools for techniques like immunoprecipitation, ChIP-seq, and immunofluorescence to investigate chromatin remodeling mechanisms. Dysregulation of BAF155 is linked to cancers (e.g., ovarian, breast) and neurodevelopmental disorders, with studies showing both tumor-suppressive and oncogenic roles depending on cellular context.

Commercial BAF155 antibodies are typically raised against epitopes in its conserved N-terminal or C-terminal regions. However, variability in antibody specificity (due to splice isoforms or post-translational modifications) necessitates validation via knockout controls. Research using these antibodies has highlighted BAF155's role in maintaining pluripotency, X-chromosome inactivation, and its crosstalk with Polycomb repressive complexes, underscoring its centrality in epigenetic regulation.