Triosephosphateisomerase抗体;Triosephosphateisomerase Antibody—艾普蒂 新品

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     Western blot analysis of Triosephosphate isomerase expression in HeLa cell lysate.    

  
  

Triosephosphate isomerase (TIM) antibodies are immunological tools targeting the enzyme triosephosphate isomerase, a crucial glycolytic protein responsible for catalyzing the reversible interconversion of dihydroxyacetone phosphate (DHAP) and glyceraldehyde-3-phosphate (G3P). This enzyme plays a central role in energy production, making it essential in all living organisms. Structurally, TIM exists as a homodimer with highly conserved sequences across species, which facilitates its study using antibodies in diverse biological models.

TIM antibodies are widely employed in research to investigate metabolic pathways, cellular stress responses, and diseases linked to TIM dysfunction. For instance, TIM deficiency in humans is associated with hemolytic anemia and neurological disorders. Additionally, TIM overexpression has been implicated in cancer progression, where it supports tumor cell proliferation via enhanced glycolysis. Antibodies against TIM enable detection of its expression levels in tissues or cell lysates using techniques like Western blotting, immunohistochemistry, or immunofluorescence.

In autoimmune contexts, TIM autoantibodies have been identified in conditions such as systemic lupus erythematosus (SLE), suggesting its potential role as an autoantigen. Researchers also explore TIM antibodies to develop diagnostic assays or therapeutic strategies targeting metabolic vulnerabilities in diseases. Their cross-reactivity with TIM orthologs in pathogens (e.g., parasites, bacteria) further expands applications in infectious disease studies. Overall, TIM antibodies serve as vital reagents for elucidating metabolic regulation and disease mechanisms.