SF3B1抗体;SF3B1 Antibody—艾普蒂

The SF3B1 antibody targets the SF3B1 (Splicing Factor 3B Subunit 1) protein, a core component of the spliceosome responsible for pre-mRNA processing. SF3B1 plays a critical role in recognizing branch site sequences during the splicing process, ensuring precise removal of introns and ligation of exons. Mutations in the *SF3B1* gene are frequently observed in cancers such as myelodysplastic syndromes (MDS), chronic lymphocytic leukemia (CLL), and uveal melanoma, often correlating with aberrant splicing and disease progression. Antibodies against SF3B1 are widely used in research to study its expression, localization, and interaction partners in normal and pathological contexts. They enable detection of SF3B1 protein levels via techniques like Western blotting, immunohistochemistry, or immunofluorescence, aiding in understanding its role in splicing dysregulation. Additionally, SF3B1 antibodies help identify mutant variants or assess post-translational modifications linked to cellular stress or therapeutic resistance. Their diagnostic potential is emerging, particularly in hematologic malignancies, where SF3B1 mutations serve as biomarkers for prognosis or targeted therapy. However, challenges remain in distinguishing wild-type from mutant isoforms using standard antibodies, driving the development of mutation-specific reagents. Overall, SF3B1 antibodies are vital tools for unraveling splicing biology and its implications in disease.