PDE4B抗体;PDE4B Antibody—艾普蒂 新品

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     Western blot analysis of PDE4B expression in A549 cell lysate.    

  
  

PDE4B (phosphodiesterase 4B) is a member of the PDE4 enzyme family that specifically hydrolyzes cyclic adenosine monophosphate (cAMP), a critical secondary messenger regulating diverse cellular processes, including inflammation, immune responses, and neuronal signaling. PDE4B is highly expressed in immune cells, the brain, and other tissues, and its activity modulates cAMP levels, thereby influencing pathways linked to cell proliferation, differentiation, and apoptosis. Dysregulation of PDE4B has been implicated in various diseases, such as chronic obstructive pulmonary disease (COPD), asthma, depression, and certain cancers, making it a target for therapeutic intervention.

PDE4B antibodies are essential tools for studying the enzyme's expression, localization, and function in both physiological and pathological contexts. They enable detection of PDE4B protein levels in tissues or cell lysates via techniques like Western blotting, immunohistochemistry, or flow cytometry. Additionally, these antibodies aid in elucidating PDE4B's role in signaling cascades and its interaction with other molecules. Research using PDE4B-specific antibodies has highlighted its involvement in inflammatory responses, where inhibition of PDE4B enhances cAMP signaling, potentially suppressing pro-inflammatory cytokine production.

The development of selective PDE4B inhibitors, such as roflumilast, underscores its clinical relevance, though challenges remain in minimizing side effects associated with off-target PDE4 family inhibition. PDE4B antibodies continue to support drug discovery and mechanistic studies, bridging gaps in understanding cAMP-mediated pathways and their therapeutic exploitation.