CPEB1抗体;CPEB1 Antibody—艾普蒂

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     Western blot analysis of CPEB1 expression in A549 cell lysate.    

  
  

The CPEB1 antibody is a crucial tool in molecular and cellular biology research, targeting the Cytoplasmic Polyadenylation Element Binding Protein 1 (CPEB1). CPEB1 is an RNA-binding protein that regulates mRNA translation and stability by binding to cytoplasmic polyadenylation elements (CPEs) in the 3' untranslated regions (UTRs) of target mRNAs. It plays pivotal roles in synaptic plasticity, memory formation, and cell cycle regulation, particularly in oocyte maturation and early embryonic development. Dysregulation of CPEB1 has been implicated in neurological disorders, cancer, and other diseases, with studies highlighting its dual role as either an oncogene or tumor suppressor depending on cellular context.

CPEB1 antibodies are widely used to detect and quantify CPEB1 expression in techniques such as Western blotting, immunohistochemistry (IHC), immunofluorescence (IF), and co-immunoprecipitation (Co-IP). These antibodies aid in studying CPEB1's subcellular localization, interaction partners, and functional mechanisms in diverse biological processes. Researchers rely on validated CPEB1 antibodies to explore its involvement in mRNA translational control during long-term potentiation (LTP) in neurons, its impact on cancer progression via regulating oncogenic or tumor-suppressive mRNAs, and its role in cellular stress responses. Specificity and reliability of these antibodies are typically confirmed using knockout controls or siRNA-mediated knockdown. As CPEB1's functions continue to be elucidated, its antibodies remain essential for deciphering its contributions to both physiological and pathological states.