STF1抗体;STF1 Antibody—艾普蒂 新品

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     All lanes use the Antibody at 1:2K dilution for 1 hour at room temperature.    

  
  

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     Western blot analysis of STF1 expression in Jutkat cell lysate.    

  
  

The STF1 antibody is primarily associated with the detection and study of the Siamois Transcription Factor 1 (STF1), a protein critical in early embryonic development, particularly in *Xenopus laevis* (African clawed frog). STF1 is a key mediator of the Wnt/β-catenin signaling pathway, which regulates axial patterning and organizer formation during vertebrate embryogenesis. It binds to DNA in conjunction with β-catenin and TCF/LEF family proteins to activate target genes like *Siamois* and *Xnr3*, which initiate dorsal axis specification.

Developed as a research tool, the STF1 antibody enables the identification and localization of the STF1 protein in experimental models. It has been widely used in immunoprecipitation, Western blotting, and immunofluorescence to investigate Wnt signaling dynamics, transcriptional regulation, and cell fate determination. Studies employing this antibody have clarified mechanisms underlying embryonic patterning, stem cell differentiation, and tissue regeneration.

Additionally, aberrant Wnt/STF1 activity is implicated in cancers, making the antibody relevant in oncology research to explore pathways driving tumorigenesis or metastasis. Its specificity and reliability depend on epitope conservation across species, though cross-reactivity may vary. Overall, the STF1 antibody remains a vital reagent for developmental biology and disease-related studies tied to Wnt signaling dysregulation.