VGLUT1抗体;VGLUT1 Antibody—艾普蒂

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     Western blot analysis of VGluT1 expression in Neuro-2a cell lysate.    

  
  

Vesicular glutamate transporter 1 (VGLUT1), encoded by the *SLC17A7* gene, is a transmembrane protein responsible for packaging glutamate into synaptic vesicles, a critical step in excitatory neurotransmission. As one of three VGLUT isoforms (VGLUT1-3), it is predominantly expressed in the central nervous system, particularly in cortical and hippocampal glutamatergic neurons, cerebellar mossy fibers, and sensory pathways. Its expression is often used as a marker for neurons specializing in glutamate-mediated signaling.

VGLUT1 antibodies are widely employed in neuroscience research to identify and map glutamatergic pathways, study synaptic plasticity, and investigate neurological disorders linked to glutamate dysregulation, such as Alzheimer’s disease, schizophrenia, and epilepsy. These antibodies enable visualization of VGLUT1 distribution via techniques like immunohistochemistry, Western blotting, and immunofluorescence. Specificity is crucial, as VGLUT1 shares structural homology with VGLUT2 and VGLUT3. which have distinct regional and functional roles. Validated antibodies help differentiate these isoforms, supporting studies on their unique contributions to neural circuits and behavior.

Research using VGLUT1 antibodies has also clarified its role in synapse development, neurotransmitter release dynamics, and disease-associated changes in glutamate homeostasis, making it a key tool for understanding excitatory signaling in health and disease.