Matrin3抗体;Matrin3 Antibody—艾普蒂 新品

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     Western blot analysis of Matrin 3 expression in (1) HEK293 cell lysate; (2) PC12 cell lysate.    

  
  

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     All lanes use the Antibody at 1:2K dilution for 1 hour at room temperature.    

  
  

Matrin3 is a highly conserved nuclear matrix protein encoded by the MATR3 gene, primarily localized in the nucleus where it plays critical roles in DNA repair, RNA metabolism, and chromatin organization. It contains two zinc finger domains and two RNA recognition motifs, enabling interactions with nucleic acids and multiprotein complexes. Matrin3 antibodies are essential tools for studying its expression, localization, and functional mechanisms in both physiological and pathological contexts. These antibodies are widely used in techniques like Western blotting, immunofluorescence (IF), and immunohistochemistry (IHC) to investigate Matrin3's involvement in transcriptional regulation, mRNA stability, and alternative splicing.

Research has linked Matrin3 mutations to neurodegenerative diseases, including amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD), making its antibodies valuable for exploring disease mechanisms. Commercially available Matrin3 antibodies are typically raised against specific epitopes, such as the N-terminal or C-terminal regions, and vary in host species (e.g., rabbit, mouse) and clonality (monoclonal/polyoclonal). Validation data, including reactivity in human, mouse, or rat samples, are crucial for ensuring specificity. Recent studies also utilize these antibodies to probe Matrin3's role in stress granule formation and viral replication, highlighting its multifaceted cellular functions. Proper controls, such as knockout cell lines, are recommended to confirm antibody specificity in experimental settings.