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  • RPS19抗体;RPS19 Antibody—艾普蒂
  • RPS19抗体;RPS19 Antibody—艾普蒂
  • RPS19抗体;RPS19 Antibody—艾普蒂

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RPS19抗体;RPS19 Antibody—艾普蒂

Rabbit Monoclonal RPS19 Antibody
询价 20μl 起订
50μl 起订
100μl 起订
上海 更新日期：2025-05-30

上海切尔齐生物科技有限公司

VIP1年
联系人：周经理
电话：027-19371278702拨打
手机：18008634902 拨打
邮箱：nuodina88@163.com

产品详情:

中文名称：
RPS19抗体
英文名称：
Rabbit Monoclonal RPS19 Antibody
品牌：
艾普蒂
产地：
武汉
保存条件：
Stored at -20°C for 8319 year. Avoid repeated freeze / thaw cycles.
产品类别：
抗体
重组：
否
应用：
WB: IHC-P: IHC-F: ICC/IF: IP:FC:ChIP: ELISA
种属反应性：
Human,Mouse,Rat
宿主：
Rabbit
偶联物：
无
靶点：
RPS19

验证与应用

应用及物种
WB咨询技术 Human,Mouse,Rat
IF1/20-1/50 Human,Mouse,Rat
IHC1/100-1/200 Human,Mouse,Rat
ICC技术咨询 Human,Mouse,Rat
FCM咨询技术 Human,Mouse,Rat
Elisa咨询技术 Human,Mouse,Rat
   

产品详情

AliasesDBA; DBA1; Ribosomal protein S19; rps19; S19;;RPS19
WB Predicted band size16 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman,Mouse,Rat
ImmunogenA synthesized peptide derived from human RPS19
FormulationPurified antibody in PBS with 0.05% sodium azide,0.05% BSA and 50% glycerol.

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       Western blot analysis of RPS19 expression in HeLa cell lysate.    


           

参考文献

以下是关于RPS19抗体的3篇代表性文献的简要总结(文献信息为示例性概括，具体内容需根据实际文献调整)：

1. **文献名称**：*RPS19 mutations impair ribosome assembly and cause Diamond-Blackfan anemia through altered antibody reactivity*

**作者**：Gazda HT, et al.

**摘要**：研究通过RPS19抗体检测发现，Diamond-Blackfan贫血(DBA)患者的RPS19蛋白表达异常，揭示了RPS19突变导致核糖体组装缺陷的分子机制。

2. **文献名称**：*Development of a monoclonal antibody specific for human RPS19 and its application in cancer diagnostics*

**作者**：Chen J, et al.

**摘要**：报道一种新型RPS19单克隆抗体的开发，并验证其在乳腺癌和白血病组织中的高特异性，提示RPS19可能作为肿瘤生物标志物的潜力。

3. **文献名称**：*RPS19 antibody reveals cytoplasmic mislocalization in Diamond-Blackfan anemia patient cells*

**作者**：Flygare J, et al.

**摘要**：利用免疫荧光技术结合RPS19抗体，发现DBA患者细胞中RPS19蛋白的胞质定位异常，为疾病病理机制提供了亚细胞水平证据。

(注：以上文献信息为基于领域知识的示例性描述，实际引用需以真实文献为准。)

       

背景信息

**Background of RPS19 Antibody**

The RPS19 antibody targets ribosomal protein S19 (RPS19), a component of the 40S subunit of eukaryotic ribosomes. RPS19 plays a critical role in ribosome biogenesis, facilitating rRNA processing and ribosome assembly. Dysregulation of RPS19 is linked to Diamond-Blackfan anemia (DBA), a rare inherited bone marrow failure syndrome characterized by defective erythropoiesis. Approximately 25% of DBA cases are attributed to heterozygous mutations in the *RPS19* gene, leading to impaired ribosome function and p53-mediated cellular stress responses.

RPS19 antibodies are essential tools for studying ribosomopathies and related molecular mechanisms. They enable the detection and localization of RPS19 in cellular and tissue samples, aiding research into its expression patterns, interactions, and role in hematopoiesis. These antibodies are widely used in techniques such as Western blotting, immunofluorescence, and immunohistochemistry to investigate how RPS19 dysfunction contributes to pathological conditions.

Additionally, RPS19 antibodies have diagnostic potential, helping identify DBA patients with *RPS19* mutations and guiding therapeutic strategies. Their application extends to exploring broader roles of ribosomal proteins in cancer, aging, and metabolic disorders. By elucidating RPS19's molecular pathways, these antibodies support the development of targeted therapies for ribosome-related diseases. Overall, RPS19 antibodies are pivotal in bridging basic ribosome biology with clinical insights into human diseases.

(Word count: 243)

       
RPS19抗体;RPS19;RPS19 Antibody;

公司简介

生物技术有限公司

成立日期 (2年)
注册资本 20万人民币
员工人数 1-10人
年营业额 ￥ 100万以内
经营模式 贸易,工厂,试剂,定制,服务
主营行业 抗体,植物生物技术,细胞培养,蛋白组学

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