ESE1抗体;ESE1 Antibody—艾普蒂 新品

The ESE1 antibody targets the ESE1 protein, also known as Elf3 or ERT, a member of the ETS family of transcription factors. ESE1 is primarily expressed in epithelial tissues and plays a critical role in regulating genes involved in cell differentiation, inflammation, and stress responses. It binds to DNA via its conserved ETS domain, modulating pathways like NF-κB and MAPK, which are pivotal in maintaining epithelial homeostasis and responding to pathological conditions. Dysregulation of ESE1 has been implicated in cancers (e.g., breast, prostate, and colon), chronic inflammatory diseases, and tissue injury. Researchers use ESE1 antibodies in techniques such as Western blotting, immunohistochemistry, and immunofluorescence to study its expression patterns, subcellular localization, and interactions in both normal and diseased states. These studies aim to elucidate ESE1's dual role as a tumor suppressor or promoter, depending on cellular context, and its potential as a therapeutic target. The antibody's specificity and reliability make it a valuable tool for exploring epithelial biology and disease mechanisms.