Adiponectin抗体;Adiponectin Antibody—艾普蒂

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     Western blot analysis of Adiponectin expression in mouse kidney cell lysate.    

  
  

Adiponectin, a hormone predominantly secreted by adipose tissue, plays a critical role in regulating metabolic processes, including glucose regulation, fatty acid oxidation, and anti-inflammatory responses. It exists in multiple oligomeric forms (low-molecular-weight, hexameric, and high-molecular-weight complexes), each with distinct biological activities. Reduced adiponectin levels are associated with obesity, insulin resistance, type 2 diabetes, and cardiovascular diseases, making it a key biomarker for metabolic syndrome research.

Antibodies targeting adiponectin are essential tools for detecting and quantifying its expression in biological samples. These antibodies are widely used in techniques like ELISA, Western blotting, and immunohistochemistry to study adiponectin's distribution, structure-function relationships, and tissue-specific roles. Monoclonal antibodies offer high specificity for particular adiponectin isoforms, while polyclonal antibodies detect broader epitopes, enhancing sensitivity for diverse applications. Researchers also utilize adiponectin antibodies to investigate its signaling pathways, receptor interactions (AdipoR1/R2), and therapeutic potential in metabolic disorders. Recent advancements include the development of recombinant antibodies and assay kits optimized for clinical diagnostics, further bridging experimental research with translational medicine. Validating these antibodies for specificity, cross-reactivity, and reproducibility remains crucial to ensure accurate data in both preclinical and clinical studies.