PMF1抗体;PMF1 Antibody—艾普蒂

The PMF1 (Polyamine Modulated Factor 1) antibody is a tool used to study the PMF1 protein, which plays a role in cellular processes such as DNA repair, cell cycle regulation, and stress response. PMF1. initially identified for its interaction with polyamines (small molecules involved in cell growth and differentiation), is implicated in modulating transcriptional activity and maintaining genomic stability. It associates with the COP9 signalosome (CSN), a complex regulating protein degradation and signaling pathways, suggesting involvement in ubiquitin-proteasome systems. Research links PMF1 to cancer biology, neurodevelopment, and apoptosis, with altered expression observed in tumors and neurodegenerative conditions. The PMF1 antibody enables detection and localization of the protein via techniques like Western blotting, immunohistochemistry, and immunofluorescence. Its applications extend to exploring PMF1's molecular interactions, post-translational modifications, and functional roles in disease models. As polyamines and their regulatory networks are therapeutic targets, understanding PMF1's mechanisms through antibody-based studies holds potential for elucidating disease pathways and developing biomarkers. Commercial PMF1 antibodies are typically raised in rabbits or mice, validated for specificity across human and rodent samples.