ACTR1B抗体;ACTR1B Antibody—艾普蒂 新品

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     Western blot analysis of ACTR1B expression in 293 cell lysate.    

  
  

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     Immunoprecipitate (IP) analysis using the Antibody at 1:50 dilution. (wb at 1:1000 dilution)    

  
  

The ACTR1B (ARP1-beta) antibody is a tool used to detect the ACTR1B protein, a member of the actin-related protein (ARP) family. ACTR1B, also known as β-centractin, plays a critical role in cellular processes involving the cytoskeleton. It interacts with the dynactin complex, which regulates dynein-mediated intracellular transport along microtubules, impacting organelle positioning, vesicle trafficking, and mitotic spindle organization. ACTR1B is structurally related to actin but lacks filament-forming ability, instead contributing to the stabilization and dynamics of cytoskeletal networks.

ACTR1B antibodies are widely utilized in research to study cell division, intracellular transport, and cytoskeletal remodeling. They are employed in techniques like Western blotting, immunofluorescence, and immunoprecipitation to determine protein expression levels, subcellular localization, and interaction partners. Dysregulation of ACTR1B has been implicated in neurodevelopmental disorders and cancer, making its antibody a valuable reagent for exploring disease mechanisms.

These antibodies are typically raised in rabbits or mice using immunogenic peptides derived from conserved regions of human ACTR1B. Validation includes testing for specificity (e.g., knockdown/knockout controls) and cross-reactivity across species (human, mouse, rat). Researchers use them to elucidate ACTR1B's role in cellular homeostasis, providing insights into pathways linked to developmental defects or metastatic behaviors in cancer.