TAOK1抗体;TAOK1 Antibody—艾普蒂

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     Western blot analysis of TAOK1 expression in (1) HeLa cell lysate; (2) RAW 264.7 cell lysate; (3) C6 cell lysate.    

  
  

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     All lanes use the Antibody at 1:2K dilution for 1 hour at room temperature.    

  
  

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     All lanes use the Antibody at 1:2K dilution for 1 hour at room temperature.    

  
  

TAOK1 (Thousand and One Amino Acid Kinase 1) is a serine/threonine kinase belonging to the STE20 family, known to regulate diverse cellular processes, including stress response, cell cycle progression, cytoskeletal dynamics, and apoptosis. It activates downstream MAPK pathways and modulates Hippo signaling, playing roles in development, neuronal function, and immune regulation. Dysregulation of TAOK1 has been implicated in cancers, neurodevelopmental disorders, and neurodegenerative diseases.

TAOK1 antibodies are essential tools for detecting and studying the expression, localization, and function of TAOK1 in biological samples. These antibodies are typically generated using immunogens derived from specific regions of the TAOK1 protein (e.g., N-terminal or catalytic domains) and validated for applications such as Western blotting, immunofluorescence, immunoprecipitation, and immunohistochemistry. Monoclonal antibodies offer high specificity, while polyclonal antibodies may detect multiple epitopes, enhancing sensitivity.

Quality validation includes testing for cross-reactivity, specificity (e.g., using TAOK1-knockout controls), and performance in target experimental setups. Researchers use TAOK1 antibodies to explore its involvement in disease mechanisms, signaling crosstalk, and potential therapeutic targeting. Reliable antibodies are critical for elucidating TAOK1's roles in cellular homeostasis and pathology.