PCBP2抗体;PCBP2 Antibody—艾普蒂

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     Western blot analysis of PCBP2 expression in HeLa cell lysate.    

  
  

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     All lanes use the Antibody at 1:2K dilution for 1 hour at room temperature.    

  
  

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     All lanes use the Antibody at 1:1K dilution for 1 hour at room temperature.    

  
  

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     Immunoprecipitate (IP) analysis using the Antibody at 1:50 dilution. (wb at 1:1K dilution)    

  
  

**Background of PCBP2 Antibody**

PCBP2 (Poly(rC)-Binding Protein 2) is a member of the heterogeneous nuclear ribonucleoprotein (hnRNP) family, known for its RNA-binding activity and involvement in post-transcriptional gene regulation. It interacts with poly(rC)-rich regions in RNA, playing roles in mRNA stability, translation regulation, and alternative splicing. PCBP2 also participates in cellular processes such as iron homeostasis, viral replication, and stress response.

The PCBP2 antibody is a critical tool for detecting and studying this protein in various biological contexts. Researchers use it to investigate PCBP2's role in cancer, where it may act as both a tumor suppressor and promoter depending on cellular context. For example, PCBP2 is implicated in regulating oncogenic signaling pathways (e.g., PI3K/AKT) and has been linked to malignancies like hepatocellular carcinoma and glioblastoma. Additionally, studies utilize this antibody to explore PCBP2's interaction with viral RNAs (e.g., enteroviruses, hepatitis A virus) and its impact on viral life cycles.

Validated in assays such as Western blotting, immunohistochemistry, and immunofluorescence, the antibody aids in elucidating PCBP2's subcellular localization (primarily nuclear and cytoplasmic) and expression patterns across tissues. Its specificity and reliability make it essential for advancing research in RNA biology, cancer mechanisms, and host-pathogen interactions.