NTH1抗体;NTH1 Antibody—艾普蒂 新品

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     Western blot analysis of NTH1 expression in 293 cell lysate.    

  
  

**Background of NTH1 Antibody**

NTH1 (endonuclease III-like protein 1) is a DNA glycosylase encoded by the *NTHL1* gene, primarily involved in base excision repair (BER) of oxidative DNA damage. It recognizes and cleaves oxidized pyrimidines, such as thymine glycol and urea residues, playing a critical role in maintaining genomic stability. Dysregulation of NTH1 activity has been linked to cancer susceptibility and neurodegenerative disorders, underscoring its importance in cellular defense against reactive oxygen species (ROS)-induced damage.

NTH1 antibodies are immunological tools developed to detect and study the expression, localization, and function of the NTH1 protein. These antibodies are widely used in research applications, including Western blotting, immunohistochemistry, and immunofluorescence, to investigate NTH1's role in DNA repair mechanisms, cellular stress responses, and disease pathogenesis. For instance, studies utilizing NTH1 antibodies have elucidated its interaction with other BER pathway components and its potential as a biomarker in oxidative stress-related conditions. Commercial NTH1 antibodies are typically raised in hosts like rabbits or mice, targeting specific epitopes of the human NTH1 protein. Validation via knockout/knockdown models ensures specificity, enabling reliable analysis in both normal and pathological contexts, such as cancer or aging research.