Septin8抗体;Septin8 Antibody—艾普蒂 新品

+ +

•  

   

     Western blot analysis of Septin 8 expression in (1) HeLa cell lysate; (2) NIH/3T3 cell lysate.    

  
  

Septin8 is a member of the septin family, a group of GTP-binding proteins conserved across eukaryotes that play critical roles in cellular processes such as cytokinesis, cell polarity, membrane remodeling, and cytoskeletal organization. Septins assemble into higher-order structures, acting as scaffolds or diffusion barriers to regulate dynamic cellular events. Septin8. encoded by the *SEPTIN8* gene in humans, is implicated in diverse physiological and pathological contexts, including neuronal development, ciliogenesis, and cancer progression. Dysregulation of septins, including Septin8. has been linked to neurodegenerative disorders (e.g., Alzheimer’s disease), infertility, and tumorigenesis, underscoring their biomedical relevance.

Antibodies targeting Septin8 are essential tools for studying its expression, localization, and function. They enable detection of Septin8 in techniques like Western blotting, immunofluorescence, and immunohistochemistry, aiding investigations into its role in cellular architecture and disease mechanisms. For instance, Septin8 antibodies have been used to explore its interaction with other septins (e.g., Septin2. Septin7) in filament formation and its involvement in synaptic vesicle trafficking. In cancer research, such antibodies help assess Septin8's aberrant expression in tumors, potentially linking it to metastasis or chemoresistance. Validation of Septin8 antibodies via knockout controls or peptide competition ensures specificity, which is critical given the high homology among septin family members. Overall, Septin8 antibodies are vital for unraveling the protein’s contributions to both normal biology and disease pathways.