AAMP抗体;AAMP Antibody—艾普蒂

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     Western blot analysis of AAMP expression in (1) A375 lysate; (2) MCF7 cell lysate.    

  
  

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     All lanes use the Antibody at 1:2K dilution for 1 hour at room temperature.    

  
  

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     All lanes use the Antibody at 1:2K dilution for 1 hour at room temperature.    

  
  

AAMP (Angio-Associated Migratory Cell Protein) is a conserved cytoplasmic protein implicated in cell migration, angiogenesis, and cancer progression. Initially identified for its role in endothelial cell motility during blood vessel formation, AAMP interacts with cytoskeletal components and signaling molecules to regulate cellular adhesion and movement. Structurally, it contains multiple WD40 repeat domains, facilitating protein-protein interactions critical for its function. AAMP is expressed across various tissues and cell types, including immune cells, where it modulates inflammatory responses.

AAMP antibodies are essential tools for studying its expression, localization, and mechanistic roles in physiological and pathological contexts. In cancer research, elevated AAMP levels correlate with tumor invasiveness, metastasis, and poor prognosis, suggesting its potential as a therapeutic target or biomarker. Antibodies against AAMP enable detection via techniques like Western blotting, immunohistochemistry, and immunofluorescence, aiding investigations into its involvement in signaling pathways (e.g., Rho GTPase, integrin) and cross-talk with molecules like VEGF or HIF-1α in hypoxic microenvironments. Recent studies also explore AAMP's role in autoimmune diseases and vascular disorders. However, challenges remain in standardizing antibody specificity due to shared epitopes in WD40 domains. Ongoing research aims to clarify AAMP's dual roles in promoting or suppressing disease processes, depending on cellular context.