Anti-TrkB抗体;Anti-TrkB Antibody—艾普蒂

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     All lanes use the Antibody at 1:2K dilution for 1 hour at room temperature.    

  
  

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     All lanes use the Antibody at 1:2K dilution for 1 hour at room temperature.    

  
  

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     Western blot analysis of TrkB expression in mouse brain lysate.    

  
  

Anti-TrkB antibodies are essential tools in neuroscience and biomedical research for studying the tropomyosin receptor kinase B (TrkB), a key receptor tyrosine kinase encoded by the *NTRK2* gene. TrkB binds brain-derived neurotrophic factor (BDNF) and related neurotrophins (NT-4/5), activating downstream signaling pathways (e.g., MAPK, PI3K-Akt, PLCγ) critical for neuronal survival, differentiation, synaptic plasticity, and cognitive functions. Dysregulation of TrkB signaling is implicated in neurodegenerative disorders (Alzheimer’s, Parkinson’s), depression, epilepsy, and cancers (e.g., neuroblastoma, gliomas).

Anti-TrkB antibodies enable detection of TrkB expression, phosphorylation status, and localization via techniques like Western blot, immunohistochemistry, and immunoprecipitation. They are used to explore TrkB’s role in disease mechanisms, therapeutic responses, or neurodevelopmental processes. Some antibodies target extracellular domains to block ligand binding or intracellular regions to inhibit signaling. Additionally, TrkB-targeting therapeutic antibodies and small-molecule inhibitors (e.g., larotrectinib) are under investigation for cancer treatment. Researchers also utilize these antibodies to validate TrkB as a biomarker or assess its expression changes in disease models, aiding drug discovery and mechanistic studies. Their specificity and validation (knockout controls, ligand stimulation) are critical to ensure accurate experimental outcomes.