PSD93抗体;PSD93 Antibody—艾普蒂 新品

+ +

•  

   

     Western blot analysis of PSD93 expression in SH-SY5Y cell lysate.    

  
  

•  

   

     All lanes use the Antibody at 1:2K dilution for 1 hour at room temperature.    

  
  

•  

   

     All lanes use the Antibody at 1:2K dilution for 1 hour at room temperature.    

  
  

**Background of PSD93 Antibody**

PSD93 (Postsynaptic Density Protein 93), also known as DLG2 (Discs Large Homolog 2), is a member of the membrane-associated guanylate kinase (MAGUK) family. It is a scaffolding protein predominantly localized at the postsynaptic density (PSD) of excitatory synapses in the central nervous system. PSD93 plays a critical role in organizing synaptic signaling complexes by interacting with neurotransmitter receptors (e.g., NMDA receptors), ion channels, and downstream signaling molecules. It facilitates the clustering and stabilization of these proteins, contributing to synaptic structure, plasticity, and neurotransmission.

Antibodies targeting PSD93 are essential tools in neuroscience research, enabling the detection and characterization of PSD93 expression, distribution, and interactions. They are widely used in techniques like Western blotting, immunohistochemistry, and immunoprecipitation to study synaptic organization in both physiological and pathological contexts. Research has linked PSD93 dysfunction to neurological and psychiatric disorders, including schizophrenia, Alzheimer’s disease, and autism spectrum disorders, highlighting its importance in maintaining synaptic integrity.

PSD93 antibodies are often validated for specificity across species (e.g., human, mouse, rat) and applications, ensuring reliable results in diverse experimental models. Their use has advanced understanding of synaptic protein networks and mechanisms underlying synaptic plasticity, providing insights into potential therapeutic targets for brain disorders.