SynGAP抗体;SynGAP Antibody—艾普蒂 新品

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     All lanes use the Antibody at 1:2K dilution for 1 hour at room temperature.    

  
  

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     Western blot analysis of SynGAP expression in human fetal brain lysate.    

  
  

SynGAP (Synaptic Ras GTPase-activating protein) is a critical neuronal protein predominantly expressed in the brain, where it regulates synaptic plasticity and cognitive functions. It is enriched at excitatory postsynaptic membranes, interacting with PSD-95 and NMDA receptors. Structurally, SynGAP contains an N-terminal Pleckstrin homology (PH) domain, a C-terminal RasGAP domain, and multiple phosphorylation sites. Its primary role involves modulating Ras/ERK and Rap signaling pathways, which are essential for dendritic spine development, synaptic strength, and memory formation.

Antibodies targeting SynGAP are widely used in neuroscience research to investigate its expression, localization, and interactions. These antibodies are typically generated against specific epitopes, such as the C-terminal region, and validated via techniques like Western blotting, immunohistochemistry, or immunoprecipitation. Due to SynGAP’s splice variants and post-translational modifications, antibody specificity is crucial.

Dysregulation of SynGAP is linked to neurodevelopmental disorders, including autism, intellectual disability, and epilepsy. Heterozygous mutations in the SYNGAP1 gene are a common cause of developmental delay, driving demand for reliable SynGAP antibodies in diagnostic and therapeutic research. Commercial antibodies vary in host species (e.g., rabbit, mouse) and clonality (monoclonal/polyclonal), with applications spanning basic research, biomarker studies, and drug development. Proper validation using knockout controls ensures accurate interpretation of SynGAP’s complex roles in synaptic function and disease.