Klotho抗体;Klotho Antibody—艾普蒂

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     Red: Control Antigen (100ng); Purple: Antigen (10ng); Green: Antigen (50ng); Blue: Antigen (100ng);    

  
  

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     Immunofluorescence analysis of HepG2 cells using CD105 mouse mAb (green). Blue: DRAQ5 fluorescent DNA dye. Red: Actin filaments have been labeled with Alexa Fluor-555 phalloidin.    

  
  

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     Flow cytometric analysis of HepG2 cells using CD105 mouse mAb (green) and negative control (purple).    

  
  

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     Immunohistochemical analysis of paraffin-embedded human kidney cancer tissues (left) and stomach cancer tissues (right) using CD105 mouse mAb with DAB staining.    

  
  

Klotho antibodies are tools used to study the Klotho protein, a key player in aging and age-related diseases. Named after the Greek goddess of fate, Klotho was initially identified in 1997 as an anti-aging factor. The protein exists in two forms: membrane-bound and soluble. Membrane-bound Klotho acts as a co-receptor for fibroblast growth factor 23 (FGF23), regulating phosphate and calcium homeostasis in the kidneys. Soluble Klotho, shed from the membrane form, circulates systemically and exhibits pleiotropic functions, including antioxidant, anti-inflammatory, and metabolic regulatory effects. Reduced Klotho expression is linked to chronic kidney disease, cardiovascular disorders, neurodegeneration, and accelerated aging.

Klotho antibodies are essential for detecting protein levels in tissues or biological fluids, enabling research into its distribution, regulation, and mechanistic roles. They are widely used in techniques like Western blotting, immunohistochemistry, and ELISA. Therapeutic applications are also emerging, with some antibodies designed to enhance Klotho signaling or block its degradation. Recent studies explore their potential in treating conditions like renal fibrosis, Alzheimer’s disease, and hypertension by restoring Klotho-deficient pathways. However, challenges remain in optimizing antibody specificity, delivery, and clinical translation. Despite this, Klotho antibodies remain critical for unraveling the protein’s complex biology and advancing therapeutic strategies targeting age-related pathologies.